Endothelial nitric oxide synthase gene haplotypes affect nitrite levels in black subjects
نویسندگان
چکیده
منابع مشابه
Endothelial nitric oxide synthase polymorphism rs3918226 associated with hypertension does not affect plasma nitrite levels in healthy subjects.
Endothelial Nitric Oxide Synthase Polymorphism rs3918226 Associated With Hypertension Does Not Affect Plasma Nitrite Levels in Healthy Subjects To the Editor: Salvi et al reported that the single nucleotide polymorphism (SNP) rs3918226 in the promoter of the endothelial NO synthase (eNOS) gene was associated with hypertension. Although no functional studies show how this SNP affects eNOS, the a...
متن کاملEXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (iNOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS
Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...
متن کاملAssociation of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
متن کاملEndothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men.
OBJECTIVES Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations. In this study we compared the distribution of haplotypes involving three relevant eNOS polymorphisms (T-786C in the promoter region; b/a in intron 4, and Glu298Asp in exon 7) in healthy subjects with low and high circulating ...
متن کاملEndothelial nitric oxide synthase gene polymorphisms in giant cell arteritis.
OBJECTIVE To examine potential associations of the Glu/Asp(298) polymorphism in exon 7 and the 4a/b polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene with susceptibility to and clinical expression of giant cell arteritis (GCA), particularly in patients with versus those without ischemic complications. METHODS Ninety-one consecutive patients with biopsy-proven GCA, ...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2010
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2010.52